Latest Data Release March 3, 2016

The latest updates to the online public resources available through the Allen Brain Atlas data portal were released on March 3, 2016. These include new data to two existing resources and a new product debut.

Highlights include:

  • New resource: Aging, Dementia and TBI study
    • The Aging, Dementia, and Traumatic Brain Injury (TBI) Study is a new resource with neuropathologic and molecular characterization of brains from TBI and control cases in a unique aged population-based study from a cohort from the Adult Changes in Thought (ACT) study. The brain regions assessed include parietal cortex, temporal cortex, hippocampus and cortical white matter.
    • This data release includes histology and immunohistochemistry data with quantitative image metrics to assess overall local pathological state of the tissue, protein quantification of several pathological targets, measurements of oxidative stress, in situ hybridization data with genes for canonical markers for major cell classes, RNA-sequencing data on the same regions assessed for pathological changes, and de-identified clinical data for each case.
  • New data: Allen Cell Types Database
    • The amount of data, data modalities, and structures assayed for cell types have been expanded for this public release.
    • The number of single cells from the mouse visual cortex with electrophysiological and morphological data and models (both point neuron models and biophysical models) has been increased and also includes data from additional Cre lines.
    • In collaboration with the Blue Brain Project, this is the first data release of an additional type of model, biophysical models-all active, on a subset of cells with morphological reconstructions.
    • This update also contains single cell RNA-sequencing data from the lateral geniculate nucleus, with RNA-Seq data from other structures to become available in future data releases.
  • New data: Allen Mouse Brain Connectivity Atlas
    • An initial dataset for layer-specific connectivity in the visual cortex has been released, including more precise targeting of tracers to visual areas using intrinsic signal imaging to functionally map regions before injections. This update also includes data generated with a novel viral tracer to specifically label synaptic terminals.
    • Source injection sites have been recalculated using registration to the Allen Mouse Common Coordinate Framework, replacing the original manual association.